Health Encyclopedia

Necrotizing soft tissue infection

Definition

Necrotizing soft tissue infection is a rare but very severe type of bacterial infection. It can destroy the muscles, skin, and underlying tissue. The word "necrotizing" refers to something that causes body tissue to die.

Alternative Names

Necrotizing fasciitis; Fasciitis - necrotizing; Flesh-eating bacteria; Soft tissue gangrene; Gangrene - soft tissue

Causes

Many different types of bacteria can cause this infection. A very severe and usually deadly form of necrotizing soft tissue infection is due to the bacteria Streptococcus pyogenes, which is sometimes called "flesh-eating bacteria" or strep.

Necrotizing soft tissue infection develops when the bacteria enters the body, usually through a minor cut or scrape. The bacteria begin to grow and release harmful substances (toxins) that kill tissue and affect blood flow to the area. With flesh-eating strep, the bacteria also make chemicals that block the body's ability to respond to the organism. As the tissue dies, the bacteria enters the blood and rapidly spreads throughout the body.

Symptoms

Symptoms may include:

A small, red, painful lump or bump on the skin that spreads
A very painful bruise-like area then develops and grows rapidly, sometimes in less than an hour
The center becomes dark and dusky and then turns black and the tissue dies
The skin may break open and ooze fluid

Other symptoms may include:

Feeling ill
Fever
Sweating
Chills
Nausea
Dizziness
Weakness
Shock

Exams and Tests

Your health care provider may be able to diagnose this condition by looking at your skin. Or, the condition may be diagnosed in an operating room by a surgeon.

Tests that may be done include:

Ultrasound
X-ray or CT scan
Blood tests
Blood culture to check for bacteria
An incision of the skin to see if pus is present
Skin tissue biopsy and culture

Treatment

Treatment is needed right away to prevent death. You'll likely need to stay in the hospital. Treatment includes:

Powerful antibiotics given through a vein (IV)
Surgery to drain the sore and remove dead tissue
Special medicines called donor immunoglobulins (antibodies) to help fight the infection in some cases

Other treatments may include:

Skin grafts after the infection goes away to help your skin heal and look better
Amputation if the disease spreads through an arm or leg
Hundred percent oxygen at high pressure (hyperbaric oxygen therapy) for certain types of bacterial infections

Outlook (Prognosis)

How well you do depends on:

Your overall health (especially if you have diabetes)
How fast you were diagnosed and how quickly you received treatment
The type of bacteria causing the infection
How quickly the infection spreads
How well treatment works

This disease commonly causes scarring and skin deformity.

Death can occur rapidly without proper treatment.

Possible Complications

Complications that may result from this condition include:

Infection that spreads throughout your body, causing a blood infection (sepsis), which can be deadly
Scarring and disfigurement
Loss of your ability to use an arm or leg
Death

When to Contact a Medical Professional

This disorder is severe and may be life threatening. Contact your provider right away if symptoms of infection occur around a skin injury, including:

Drainage of pus or blood
Fever
Pain
Redness
Swelling

Prevention

Always clean the skin thoroughly after a cut, scrape, or other skin injury.

References

Abbas M, Uçkay I, Ferry T, Hakko E, Pittet D. Severe soft-tissue infections. In: Bersten AD, Handy JM, eds. Oh's Intensive Care Manual. 8th ed. Philadelphia, PA: Elsevier; 2019:chap 72.

Fitzpatrick JE, High WA, Kyle WL. Necrotic and ulcerative skin disorders. In: Fitzpatrick JE, High WA, Kyle WL, eds. Urgent Care Dermatology: Symptom-Based Diagnosis. Philadelphia, PA: Elsevier; 2018:chap 14.

Pasternack MS, Swartz MN. Cellulitis, necrotizing fasciitis, and subcutaneous tissue infections. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 93.

Review Date:10/11/2023
Reviewed By:Elika Hoss, MD, Assistant Professor of Dermatology, Mayo Clinic, Scottsdale, AZ. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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